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Impact of chronic fluorosis on left ventricular diastolic and global functions

Ercan Varol1, Selahattin Akcay, I Hakki Ersoy

  • 1Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. drercanvarol@yahoo.com

The Science of the Total Environment
|March 9, 2010
PubMed

Insights

Endemic fluorosis patients exhibit impaired heart function. Chronic exposure to fluoride significantly affects left ventricular diastolic and global performance, as indicated by echocardiographic measurements.

Area of Science:

  • Cardiology
  • Environmental Health
  • Toxicology

Background:

  • Endemic fluorosis is a public health concern linked to elevated fluoride intake.
  • Cardiac involvement in chronic fluorosis is not fully understood.
  • Echocardiography can assess cardiac function, including diastolic parameters.

Purpose of the Study:

  • To investigate left ventricular diastolic and global function in patients with endemic fluorosis.
  • To compare echocardiographic parameters between fluorosis patients and healthy controls.

Main Methods:

  • Echocardiographic measurements including left ventricular diastolic parameters and myocardial performance index (MPI) were performed.
  • MPI was calculated using Doppler-derived timings: (isovolumic contraction time + isovolumic relaxation time) / aortic ejection time.
  • Urine fluoride levels were measured to confirm fluorosis status.

Main Results:

  • Fluorosis patients had significantly higher urine fluoride levels compared to controls.
  • Patients with endemic fluorosis showed significantly prolonged isovolumic relaxation time (IVRT) and deceleration time (DT).
  • A significantly higher left ventricular myocardial performance index (MPI) was observed in fluorosis patients.

Conclusions:

  • Chronic endemic fluorosis is associated with left ventricular diastolic dysfunction.
  • Elevated fluoride exposure leads to impaired global cardiac function in patients.
  • Echocardiography is a valuable tool for detecting cardiac abnormalities in fluorosis.

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