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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
Published on: January 25, 2018
Discovery of sulfonamide-pyrazole gamma-secretase inhibitors
Matthew N Mattson1, Martin L Neitzel, David A Quincy
1Elan Pharmaceuticals, 800 Gateway Blvd., South San Francisco, CA 94080, United States.
Bioorganic & Medicinal Chemistry Letters
|March 9, 2010
Abstract:
Utilizing a pharmacophore hypothesis, previously described gamma-secretase inhibiting HTS hits were evolved into novel tricyclic sulfonamide-pyrazoles, with high in vitro potency, good brain penetration, low metabolic stability, and high clearance.

