Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Acid-Base Balance01:29

Disorders of Acid-Base Balance

The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Diagnosing Acidosis and Alkalosis01:24

Diagnosing Acidosis and Alkalosis

Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2  and HCO3−  values are examined to...
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
Homeostatic Imbalance01:10

Homeostatic Imbalance

Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
Base-pairing and DNA Repair02:27

Base-pairing and DNA Repair

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Algorithm for Surgical Management of Temporal Migraine Headaches: A 25-Year Retrospective Observational Review.

Plastic and reconstructive surgery·2026
Same author

Frequency of Migraine and Sinus Headaches in Patients Undergoing Primary Rhinoplasty.

Aesthetic surgery journal·2026
Same author

What Makes Rhinoplasty Challenging? Some Answers from 45+ Years of Clinical Experience.

Plastic and reconstructive surgery·2025
Same author

Aspects and Concepts of What I Preserve in Rhinoplasty: Proceedings of the 2025 American Society of Plastic Surgeons Spring Meeting.

Plastic and reconstructive surgery·2025
Same author

Prevalence of Nasal Airway Obstruction in an Orthodontic Population Using the NOSE Scale.

Orthodontics & craniofacial research·2025
Same author

Improving Surgeon Well-Being: A Survey on Ergonomic Challenges and Solutions in Rhinoplasty.

Facial plastic surgery & aesthetic medicine·2024
Same journal

Lower-Extremity Reconstruction: Principles, Progress, and Perspectives.

Clinics in plastic surgery·2026
Same journal

Pediatric.

Clinics in plastic surgery·2026
Same journal

Lower Extremity Reconstruction in Acute Burns.

Clinics in plastic surgery·2026
Same journal

Chronic Lower Extremity Wounds: Updates on Lower Extremity Reconstruction in Clinics in Plastic Surgery.

Clinics in plastic surgery·2026
Same journal

Updates in Lower Extremity Reconstruction: Post Sarcoma.

Clinics in plastic surgery·2026
Same journal

Fillet Flaps for Lower Extremity Salvage.

Clinics in plastic surgery·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2026

Competitive Genomic Screens of Barcoded Yeast Libraries
11:59

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

Alar base disharmonies.

Diana Ponsky1, Bahman Guyuron

  • 1Department of Otolaryngology and Plastic Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Mailstop LK5045, Cleveland, OH 44106, USA. diana.ponsky@uhhospitals.org

Clinics in Plastic Surgery
|March 9, 2010
PubMed
Summary
This summary is machine-generated.

Rhinoplasty planning often neglects the nasal base, leading to irreversible functional issues. This article presents a simplified classification of alar base disharmonies to guide surgical correction.

More Related Videos

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA
10:40

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA

Published on: September 10, 2013

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
08:48

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System

Published on: December 21, 2016

Related Experiment Videos

Last Updated: Jun 15, 2026

Competitive Genomic Screens of Barcoded Yeast Libraries
11:59

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA
10:40

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA

Published on: September 10, 2013

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
08:48

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System

Published on: December 21, 2016

Area of Science:

  • Plastic Surgery
  • Facial Anatomy
  • Surgical Planning

Background:

  • The nasal base is a critical but frequently overlooked component in rhinoplasty.
  • Improper correction of alar base disharmonies can result in irreversible aesthetic and functional deficits.

Observation:

  • Common alar base disharmonies present distinct challenges in rhinoplasty.
  • Accurate recognition of these disharmonies is essential for successful surgical outcomes.

Findings:

  • This article introduces a simplified classification system for common alar base disharmonies.
  • The classification aids in identifying specific alar base flaws encountered during rhinoplasty.

Implications:

  • Facilitates the selection of appropriate surgical techniques for alar base correction.
  • Aims to improve functional and aesthetic results in rhinoplasty by addressing nasal base issues.
  • Enhances surgical planning and patient outcomes in reconstructive and aesthetic nasal surgery.