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Cell culture model systems to study HDV expression, replication and pathogenesis
E J Gowans1, T B Macnaughton, A R Jilbert
1Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, Australia.
Abstract:
Due to the transient nature of HDV replication in natural and experimental hosts and to the inability of the virus to replicate in easily handled cell lines, studies of the replication and expression of HDV have been impeded. These difficulties have been overcome by the development of the cell lines described in this paper.