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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Lineage Commitment

Commitment is the  process whereby stem cells:
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Updated: Jun 15, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior.

Timm Schroeder1

  • 1Helmholtz Center Munich, Institute of Stem Cell Research, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany. timm.schroeder@helmholtz-muenchen.de

Cell Stem Cell
|March 9, 2010
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cells (HSCs) are well-studied, but new subtypes reveal unexpected diversity. This challenges current understanding of HSC heterogeneity and its origins.

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

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Last Updated: Jun 15, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Immunology

Background:

  • Hematopoietic stem cells (HSCs) are extensively characterized using functional assays and isolation techniques.
  • Recent discoveries indicate novel HSC subtypes within established populations, challenging existing paradigms.

Purpose of the Study:

  • To investigate the heterogeneity of hematopoietic stem cell populations.
  • To re-evaluate the fundamental basis of HSC diversity.

Main Methods:

  • Utilized advanced quantitative functional assays.
  • Employed prospective isolation methods for cell sorting.
  • Analyzed recently identified HSC subtypes.

Main Results:

  • Confirmed the existence of distinct HSC subtypes.
  • Demonstrated unique properties within previously homogenous HSC populations.
  • Identified novel sources of HSC heterogeneity.

Conclusions:

  • Current understanding of HSC heterogeneity requires revision.
  • New HSC subtypes necessitate a re-examination of HSC biology.
  • Further research is needed to elucidate the functional implications of HSC subtypes.