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Coronary artery disease in patients with peripheral artery disease

Nilüfer Ekşi Duran1, Ibrahim Duran, Emre Gürel

  • 1Department of Cardiology, Kosuyolu Heart and Research Hospital, Istanbul, Turkey. eksduran@yahoo.com

Heart & Lung : the Journal of Critical Care
|March 9, 2010
PubMed

Insights

Peripheral artery disease (PAD) patients frequently have coronary artery disease (CAD). Hypertension and diabetes are key predictors of CAD in individuals with lower extremity PAD, highlighting the need for aggressive risk factor management.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery
  • Interventional Cardiology

Background:

  • Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis.
  • PAD significantly increases cardiovascular morbidity and mortality.
  • Understanding co-existing coronary artery disease (CAD) in PAD patients is crucial.

Purpose of the Study:

  • To determine the prevalence of angiographic coronary artery disease (CAD) in patients with lower extremity PAD.
  • To evaluate the predictive value of traditional cardiovascular risk factors for CAD in this population.

Main Methods:

  • A cohort of 231 patients with intermittent claudication underwent simultaneous peripheral and cardiac angiography.
  • Data collected included age, gender, hypertension, diabetes, smoking status, and lipid profiles.
  • Logistic regression analysis was employed to identify predictors of CAD.

Main Results:

  • Coronary artery disease (CAD) was detected in 72% of patients with peripheral artery disease (PAD).
  • Hypertension and diabetes were identified as independent predictors for the presence of CAD in PAD patients.
  • Only 28% of patients had normal coronary angiograms.

Conclusions:

  • The high prevalence of CAD in PAD patients underscores the systemic nature of atherosclerosis.
  • Aggressive management of hypertension and diabetes is critical for reducing mortality and morbidity in PAD.
  • Early detection and intervention for cardiovascular risk factors are essential in PAD management.
Abstract

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