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Intraventricular meningioma after cranial irradiation for childhood leukemia
Douglas E Ney1, Jason T Huse, Ira J Dunkel
1Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Abstract:
Meningiomas are among the most common brain tumors in adults. They are most commonly located over the cerebral convexities and are infrequently found in an intraventricular location. Ionizing cranial radiation is a risk factor for late occurrence of meningiomas within the radiation field. While pathologic grading of meningiomas is straightforward, significant variability often exists between pathologists in applying standard grading criteria. This has implications for prognosis. Radiation-induced meningiomas may also have predilection to recur. The authors describe a case of an intraventricular meningioma occurring 23 years after cranial irradiation for childhood acute lymphoblastic leukemia.
Insights
This study presents a rare case of an intraventricular meningioma, a brain tumor, that developed 23 years after cranial radiation therapy for childhood leukemia.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiation oncology
Background:
- Meningiomas are common adult brain tumors, typically found on cerebral convexities.
- Intraventricular meningiomas are rare, posing diagnostic and therapeutic challenges.
- Cranial radiation is a known risk factor for developing meningiomas.
Observation:
- A case of an intraventricular meningioma is described.
- The tumor occurred 23 years post-cranial irradiation for acute lymphoblastic leukemia.
- This highlights a potential long-term complication of childhood cancer treatment.
Findings:
- Pathologic grading of meningiomas can exhibit inter-observer variability, impacting prognosis.
- Radiation-induced meningiomas may show a higher propensity for recurrence.
- This case underscores the possibility of late-onset intraventricular meningiomas following cranial irradiation.
Implications:
- Increased vigilance for late-onset meningiomas in patients with a history of cranial irradiation.
- Importance of standardized pathological grading criteria for meningiomas.
- Consideration of intraventricular meningiomas in the differential diagnosis for patients with prior cranial radiation exposure.
