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Updated: Jun 15, 2026

Inducible T7 RNA Polymerase-mediated Multigene Expression System, pMGX
Published on: June 27, 2017
Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus
D Cole Stevens1, Michael R Henry, Kimberly A Murphy
1Department of Chemistry, Syracuse University, Syracuse, New York 132441, USA.
Abstract:
New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.
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