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Related Experiment Videos

[Vessel wall lipids in human atherosclerosis].

S G Aptekar', A M Vikhert

    Voprosy Meditsinskoi Khimii
    |November 1, 1977
    PubMed
    Summary

    As people age, linoleic acid increases in aortic cholesterol esters, matching low-density lipoproteins. This suggests blood lipoproteins contribute to lipid accumulation in the aorta, impacting cardiovascular health.

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    [Changes in the course of atherosclerosis occurring over a 25-year period in the male population of 9 cities of the CIS and Baltic countries].

    Terapevticheskii arkhiv·1995

    Area of Science:

    • Biochemistry
    • Cardiovascular Biology
    • Aging Research

    Context:

    • Atherosclerosis involves lipid accumulation in the aorta.
    • Aging alters the composition of aortic lipids.
    • Low-density lipoproteins (LDL) are implicated in cardiovascular disease.

    Purpose:

    • To investigate changes in cholesterol ester fatty acid composition in the human aorta during aging.
    • To determine the source of lipids accumulating in the aortic intima and atherosclerotic plaques.
    • To compare lipid profiles in different stages of aortic lesion development.

    Summary:

    • Cholesterol esters in the aging aortic intima show increased linoleic acid, resembling LDL in individuals over 50.
    • Extracellular lipid accumulation occurs in the aorta with age, particularly in fibrous plaques.
    • Lipoproteins of low density (LDL) from blood serum are identified as a likely source for aortic lipid accumulation.
    • Early lesions (lipid spots) exhibit lower linoleic acid and higher oleic acid in cholesterol esters compared to advanced lesions.

    Impact:

    • Provides insight into the mechanisms of age-related aortic lipid deposition.
    • Highlights the role of LDL in atherogenesis and aortic aging.
    • Suggests potential targets for interventions aimed at preventing or slowing atherosclerosis progression.

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