Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A glimpse into the CyberKnife robotic radiosurgery system: technical specifications and developments during thirty years.

Frontiers in oncology·2026
Same author

The quality and reliability of short videos about liver transplantation and lung transplantation on BiliBili and TikTok: cross-sectional study.

Scientific reports·2026
Same author

Cyclist behavioral persistence across consecutive intersections: Re-ID based analysis and intention prediction.

Accident; analysis and prevention·2026
Same author

Interleukin-19 ameliorates drug-induced liver injury by limiting proinflammatory macrophage infiltration via SUMOylation of C/EBPβ.

Journal of hepatology·2026
Same author

Hypofractionated stereotactic radiation therapy for optic nerve sheath meningiomas: A single-center experience and preliminary results.

Radiation oncology (London, England)·2026
Same author

Case report: Helical tomotherapy-based whole lung irradiation with simultaneous integrated boost for pulmonary metastatic Ewing's sarcoma: a case series report and feasibility analysis.

Frontiers in oncology·2026

Related Experiment Video

Updated: Jun 15, 2026

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue
17:38

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue

Published on: April 27, 2012

Molecular optical imaging with radioactive probes.

Hongguang Liu1, Gang Ren, Zheng Miao

  • 1Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University, Stanford, California, United States of America.

Plos One
|March 9, 2010
PubMed
Summary

Radioactive probes can now be used for in vivo molecular optical imaging (OI). This novel technique successfully generated optical images of various radioactive tracers, offering a new strategy for disease tracking.

More Related Videos

In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles
09:04

In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles

Published on: May 2, 2014

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jun 15, 2026

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue
17:38

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue

Published on: April 27, 2012

In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles
09:04

In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles

Published on: May 2, 2014

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Area of Science:

  • Biomedical imaging
  • Radiochemistry
  • Molecular imaging

Background:

  • Optical imaging (OI) techniques like bioluminescence and fluorescence are vital for non-invasive disease tracking in vivo.
  • These methods typically rely on specialized bioluminescent and fluorescent probes.
  • This study explores the use of radioactive probes for in vivo molecular OI.

Purpose of the Study:

  • To demonstrate the feasibility of using radioactive probes for in vivo molecular optical imaging.
  • To establish a novel molecular imaging strategy utilizing radioactivity.

Main Methods:

  • Utilized the optical window of light (400-1000 nm) emitted from radioactive decay.
  • Employed an optical imaging instrument to detect charged particles (beta(+) and beta(-)) emitted by radionuclides.
  • Tested various radioactive probes, including [(18)F]FDG, Na(18)F, Na(131)I, (90)YCl(3), and a (90)Y-labeled peptide.

Main Results:

  • Successfully obtained in vivo optical images using radioactive probes.
  • Demonstrated successful imaging of beta(+)- and beta(-)-emitting radionuclides.
  • Visualized tumor-targeting radioactive probes in vivo.

Conclusions:

  • The radioactive optical imaging technique is generalizable.
  • This represents a new molecular imaging strategy with potential for significant impact.
  • The technique is applicable to both small animal and clinical imaging settings.