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Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana
Jude E Okokon1, Bassey S Antia, Emem E Umoh
1Department of Pharmacology and Toxicology, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com
Abstract:
The effect of ethanolic leaf extract of Lasianthera africana on experimentally induced ulcer was studied in rats. The extract (1000 - 3000mg/kg) inhibited ethanol-induced, indomethacin - induced and reserpine -induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.01). The effect of the extract was comparable to that of the standard drugs used. Thus, Lasianthera africana extract demonstrated a good antiulcer activity which supports the antiulcer effect of this plant in traditional medicine.
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