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Related Experiment Video

Updated: Jun 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Granuloma annulare.

Diptesh Gupta1, Brian Hess, Lohith Bachegowda

  • 1Department of Internal Medicine, University of Missouri-Columbia, Columbia, MO, USA. guptadi@health.missouri.edu

Thescientificworldjournal
|March 9, 2010
PubMed
Summary
This summary is machine-generated.

This case study describes a generalized granuloma annulare (GA) in a diabetic male. The condition presented as a long-term, asymptomatic, migratory rash, diagnosed via skin biopsy.

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Published on: December 15, 2011

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Granuloma annulare (GA) is a benign, self-limiting skin condition with unknown etiology.
  • GA is often asymptomatic and associated with diabetes mellitus, HIV, and certain malignancies.
  • Typical GA lesions begin as flesh-colored papules forming annular plaques with central clearing.

Observation:

  • A 77-year-old diabetic male presented with a 20-year history of a generalized, asymptomatic, migratory, erythematous rash.
  • Physical examination revealed diffuse, symmetrical annular erythematous plaques with central clearing on the torso and arms.
  • Skin punch biopsy confirmed the diagnosis of generalized granuloma annulare.

Findings:

  • The patient's presentation and biopsy results were consistent with generalized granuloma annulare.
  • Key diagnostic features included the absence of symptoms, scaling, and vesicles, differentiating it from other annular erythema conditions.
  • The chronic, migratory nature of the rash over two decades was a notable aspect of this case.

Implications:

  • Generalized granuloma annulare is typically self-resolving within two years, often requiring no treatment.
  • Treatment options for cosmetic concerns include topical steroids, phototherapy, cryotherapy, or systemic agents like niacinamide or Dapsone.
  • This case highlights the importance of biopsy for diagnosing chronic, atypical skin conditions, especially in patients with comorbidities like diabetes mellitus.