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[Cartilage changes in arthrosis--do non-steroidal antiphlogistics have positive or negative effects?]
1Revmatologisk avdeling, Oslo Sanitetsforeinings, Revmatismesykehus.
Summary
Nonsteroidal anti-inflammatory drugs (NSAIDs) do not accelerate osteoarthritis progression, despite concerns about cartilage matrix synthesis. Current evidence suggests NSAIDs remain useful for managing osteoarthritis symptoms.
Area of Science:
- Biomedical Science
- Rheumatology
- Orthopedics
Context:
- Osteoarthritis (OA) treatment often involves nonsteroidal anti-inflammatory drugs (NSAIDs).
- Recent concerns question NSAID use due to potential inhibition of cartilage matrix synthesis.
- Understanding NSAID effects on articular cartilage is crucial for OA management.
Purpose:
- To review the structure of articular cartilage and osteoarthritis pathogenesis.
- To critically analyze experimental and in vivo data on NSAIDs and cartilage repair.
- To evaluate the current evidence regarding NSAID impact on human osteoarthritis progression.
Summary:
- Investigations using cell cultures, animal models, and human cartilage do not support the claim that therapeutic doses of NSAIDs accelerate human osteoarthritis.
- No convincing clinical evidence indicates detrimental or chondroprotective properties of NSAIDs in OA.
- NSAIDs can still be considered effective agents for treating osteoarthritis symptoms.
Impact:
- Provides a critical analysis of NSAID effects on cartilage, informing clinical practice.
- Reassures clinicians and patients about the continued utility of NSAIDs in OA management.
- Highlights the need for further research to clarify NSAID's role in cartilage repair and OA progression.