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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34⁺ Cells

Published on: December 27, 2017

Adolescent menorrhagia due to platelet function disorder.

Nazli Hossain¹, Tasneem Farzana, Nusrat Hasan Khan

¹Department of Obstetrics & Gynecology Unit-3, Dow University of Health Sciences & Civil Hospital Karachi.

JPMA. the Journal of the Pakistan Medical Association

|March 10, 2010

Summary

Menorrhagia affects 14-48% of adolescents with bleeding disorders. This study highlights platelet function disorders as a key cause, differing from Western findings that often cite von Willebrand disease.

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Area of Science:

Hematology
Adolescent Medicine
Gynecology

Background:

Menorrhagia is common in adolescents with bleeding disorders, with prevalence ranging from 14% to 48%.
Common causes include von Willebrand disease (VWD), platelet function disorders, and coagulation factor deficiencies.

Observation:

Geographic variations exist, with Western studies identifying VWD as the primary cause, while South-East Asian studies point to platelet function disorders.
Anovulatory bleeding and hormonal imbalances are also significant contributors to heavy menstrual bleeding in this demographic.

Findings:

This report details three cases of adolescent menorrhagia specifically caused by platelet function disorders.
A literature review complements these case studies, providing broader context on the condition.

Implications:

Recognizing platelet function disorders as a significant cause of adolescent menorrhagia is crucial for accurate diagnosis and management.
Understanding regional differences in bleeding disorder prevalence can improve targeted screening and treatment strategies for heavy menstrual bleeding.