[Severe hypoglycemia in children and adolescents suffering from type 1 diabetes mellitus]

Adriana Cosmescu1, Doina Felea, Silvia Mătăsaru

  • 1Facultatea de Medicină, Disciplina Medicină de Familie, Universitatea de Medicina Si Farmacie "Gr.T. Popa" Iaşi .

Insights

Severe hypoglycemia affects over a quarter of children with type 1 diabetes, often due to delayed carbohydrate intake. Continuous education is key to preventing this dangerous complication.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Disorders

Background:

  • Severe hypoglycemia is a significant concern for children with type 1 diabetes and their families.
  • Diabetic ketoacidosis and severe hypoglycemia are life-threatening medical emergencies.

Purpose of the Study:

  • To determine the incidence of severe hypoglycemia in pediatric patients with type 1 diabetes.
  • To identify the primary causes and risk factors associated with severe hypoglycemia episodes.

Main Methods:

  • A cohort of 84 children and adolescents with type 1 diabetes was studied over 12 months.
  • Data collected included hypoglycemia occurrence, risk factors, age, disease duration, insulin therapy, and metabolic control (HbA1c).

Main Results:

  • 27.3% (23 out of 84) of patients experienced at least one severe hypoglycemia episode.
  • The most common cause was delayed carbohydrate intake (47%), followed by high physical effort (19%) and excessive insulin (14%).
  • Episodes occurred across a range of metabolic control levels (HbA1c 6.4%-9.1%).

Conclusions:

  • Delayed carbohydrate intake is the leading preventable cause of severe hypoglycemia in this pediatric diabetic population.
  • Continuous medical education for diabetic patients is crucial for preventing acute metabolic complications like severe hypoglycemia.
Abstract

Related Concept Videos

Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...