Related Experiment Video
Updated: Jun 15, 2026
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
[Myocardial injuries induced by oxidative stress in rat--experimental morphopathological study]
M Balasanian1, Magda Bădescu, Gioconda Dobrescu
1Institutul de Boli Cardiovasculare Prof. Dr. George I. M. Georgescu, Facultatea de Medicină, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.
Unlabelled:
Oxidative stress is a phenomenon significantly involved in several clinical conditions such as ischemic heart disease and myocardial reperfusion.
Purpose:
Creating an animal model of oxidative stress based on three methods: exertional (swimming), habitual (light exposure), and corticotropine injections.
Material And Methods:
40 Wistar adult rats, weighting between 210-315 g, were subjected to either none (control group), swimming, light exposure or corticotropine injections for six weeks, then the animals were sacrificed and a light and electronic microscopic examination of the myocardium and ascending aorta were performed.
Results:
Histological features of myocardial reperfusion injury were obtained in all cases and not in the control group.
Conclusion:
All three methods consistently induce myocardial morphological injuries similar to that of the ischemia-reperfusion phenomenon, mainly the exposure to light and corticotropine injections, and mainly in the females.
