Related Experiment Video
Updated: Jun 15, 2026

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
Published on: April 3, 2026
Challenging diagnosis of ileal gastrointestinal stromal tumor presenting with obscure digestive bleeding
Luca Degrate1, Cinzia Nobili, Mattia Garancini
1Department of Surgery, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. degluc@inwind.it
Abstract:
We report a case of a patient observed in emergency condition for recurrent episodes of massive obscure gastrointestinal bleeding that required surgical control. At laparotomy we found an ileal mass with the characteristics of a gastrointestinal stromal tumor (GIST) at histopathological analysis. GISTs should always be considered as a possible cause of obscure gastrointestinal bleeding, although they are often difficult to diagnose preoperatively. Laparotomy is sometimes the only way to obtain a diagnosis. Starting from this case, we reviewed the literature about GISTs, focusing our attention on their diagnosis and the possible surgical and nonsurgical therapies.
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