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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
HPLC-based activity profiling for GABA(A) receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium
Yanfang Li1, Inken Plitzko, Janine Zaugg
1Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
Journal of Natural Products
|March 10, 2010
Abstract:
A new dihydroisocoumarin was isolated from a dichloromethane extract of Haloxylon scoparium with the aid of a functional assay with Xenopus oocytes transiently expressing GABA(A) receptors of defined subunit composition (alpha(1)beta(2)gamma(2S)). Compound 1 induced a maximum potentiation of the chloride currents by 144.6 +/- 35.3% with an EC(50) of 140.2 +/- 51.2 muM.
