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Published on: January 12, 2022
Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence
Marie J Hammer-Wilson1, Vi Nguyen, Woong-Gyu Jung
1University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92612, USA.
Abstract:
Hamster cheek pouches were exposed to 2-chloroethyl ethyl sulfide [CEES, half-mustard gas (HMG)] at a concentration of 0.4, 2.0, or 5.0 mg/ml for 1 or 5 min. Twenty-four hours post-HMG exposure, tissue damage was assessed by both stereomicrography and optical coherence tomography (OCT). Damage that was not visible on gross visual examination was apparent in the OCT images. Tissue changes were found to be dependent on both HMG concentration and exposure time. The submucosal and muscle layers of the cheek pouch tissue showed the greatest amount of structural alteration. Routine light microscope histology was performed to confirm the OCT observations.
