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Updated: Jun 15, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

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Published on: October 28, 2020

Thyroid function and left ventricular structure and function in the Framingham Heart Study.

Elizabeth N Pearce1, Qiong Yang, Emelia J Benjamin

  • 1Boston University School of Medicine, Boston, MA, USA. elizabeth.pearce@bmc.org

Thyroid : Official Journal of the American Thyroid Association
|March 10, 2010
PubMed
Summary
This summary is machine-generated.

Thyroid function is linked to heart contractility, particularly in women. Lower thyroid-stimulating hormone (TSH) levels were associated with enhanced left ventricular (LV) function in women, suggesting a role for thyroid hormone in cardiac performance.

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Area of Science:

  • Cardiology
  • Endocrinology
  • Thyroid Research

Background:

  • Thyroid hormone significantly impacts cardiac and vascular function.
  • Subclinical thyroid dysfunction can lead to subtle left ventricular (LV) changes with clinical implications.
  • Understanding the relationship between thyroid function and cardiac structure/function is crucial.

Purpose of the Study:

  • To investigate the association between thyroid function, specifically serum thyroid-stimulating hormone (TSH), and echocardiographic indices of LV structure and function.
  • To determine if thyroid status relates to LV dimensions, mass, and systolic function.

Main Methods:

  • Cross-sectional analysis of 1376 participants from the Framingham Heart Study (1979-1981).
  • Serum TSH levels were correlated with echocardiographic measurements including LV dimensions, wall thickness, mass, fractional shortening, and left atrial diameter.
  • Multivariable regression models adjusted for cardiovascular risk factors were used.

Main Results:

  • No significant association was found between TSH and LV mass, wall thickness, or left atrial size in either sex.
  • A borderline inverse association between TSH and LV fractional shortening (systolic function) was observed in women (p=0.06).
  • Women with low TSH (<0.5 mU/L) showed significantly higher odds of having enhanced LV fractional shortening (OR 2.2, p=0.01).

Conclusions:

  • TSH concentration was not associated with LV structure in this cohort.
  • Thyroid function, particularly lower TSH, was inversely related to LV contractility, especially in women.
  • Findings support the known inotropic effects of thyroid hormone on the heart.