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Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jun 15, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos

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Lenalidomide in multiple myeloma: current role and future directions.

Jerome B Zeldis1, Robert D Knight, Christian Jacques

  • 1Celgene Corporation, 86 Morris Avenue, Summit, NJ 07901, USA. jzeldis@celgene.com

Expert Opinion on Pharmacotherapy
|March 10, 2010
PubMed
Summary

Lenalidomide is an effective oral treatment for multiple myeloma, showing promise in new settings like maintenance and preventive therapy. This review details its use, safety, and management of adverse events in myeloma patients.

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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Published on: May 1, 2015

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Lenalidomide and novel agents are enhancing survival rates for multiple myeloma patients.
  • This review focuses on lenalidomide's current applications and potential in novel therapeutic contexts.

Purpose of the Study:

  • To review lenalidomide's efficacy in newly diagnosed and relapsed/refractory multiple myeloma.
  • To discuss managing adverse events associated with lenalidomide therapy.
  • To explore lenalidomide's potential in maintenance and preventive strategies.

Main Methods:

  • Literature review of clinical trials published up to 2009.
  • Analysis of lenalidomide's activity, efficacy, and safety in multiple myeloma.
  • Examination of strategies for managing myelosuppression and thromboembolic events.

Main Results:

  • Lenalidomide demonstrates efficacy in newly diagnosed, relapsed/refractory, and high-risk smoldering myeloma.
  • Management strategies for key adverse events like myelosuppression and thromboembolism are presented.
  • The mechanism of action supports lenalidomide's use in combination therapies.

Conclusions:

  • Lenalidomide is a highly effective oral immunomodulatory drug for multiple myeloma.
  • It possesses a favorable safety profile and is under investigation for maintenance and preventive roles.
  • Lenalidomide shows potential in combination with other emerging agents.