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Structure and mechanism of action of type IA DNA topoisomerases

D V Bugreev1, G A Nevinsky

  • 1Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, pr. Lavrent'eva 8, Novosibirsk, Russia.

Biochemistry. Biokhimiia
|March 10, 2010
PubMed

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Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
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