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Related Experiment Video

Updated: Jun 15, 2026

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

Nomograms for aortic root diameters in children using two-dimensional echocardiography.

Mathieu Gautier¹, Delphine Detaint, Christophe Fermanian

¹Centre de Référence pour le Syndrome de Marfan et Apparentés, Hôpital Bichat, AP-HP, Paris, France; Service de Cardiologie, Hôpital Bichat, AP-HP, Paris, France.

The American Journal of Cardiology

|March 10, 2010

Summary

New nomograms for aortic root dilation in children were developed using echocardiography. These tools aid in diagnosing and monitoring aortic root aneurysms, including in Marfan syndrome patients.

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Last Updated: Jun 15, 2026

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

Area of Science:

Cardiology
Pediatric Cardiology
Medical Imaging

Background:

Aortic root dilation is critical for diagnosing and monitoring conditions like Marfan syndrome.
Existing nomograms show discrepancies, with lower dilation rates in adults than children, contrary to expectations.

Purpose of the Study:

To establish new, accurate nomograms for aortic root diameters in children.
To provide tools for precise diagnosis and follow-up of aortic dilation in pediatric populations.

Main Methods:

Transthoracic echocardiography was used to measure aortic root diameters in 353 healthy children.
Measurements included the aortic annulus, sinuses of Valsalva, sinotubular junction, and ascending aorta.
Statistical analysis correlated diameters with height, weight, body surface area, and age, and used covariance analysis for gender differences.

Main Results:

Aortic root diameters strongly correlated with height, weight, body surface area, and age (r = 0.75–0.84).
Male children showed slightly larger sinus of Valsalva diameters than females (+1 mm, p = 0.0002) after adjusting for body surface area.
New equations and nomograms were developed for upper limit of normal and Z-scores for all measured aortic root diameters by body surface area and gender.

Conclusions:

Proposed equations and nomograms offer reliable tools for diagnosing and monitoring aortic root aneurysms in children.
The developed tools facilitate the recognition and quantification of aortic dilation, distinguishing normal growth from pathological conditions.
Application to Marfan syndrome patients revealed 65.2% had dilation of the sinuses of Valsalva, highlighting the nomograms' utility.