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Varicella disciform stromal keratitis.

K R Wilhelmus1, M B Hamill, D B Jones

  • 1Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas.

American Journal of Ophthalmology
|May 15, 1991
PubMed
Summary
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Varicella-zoster virus can cause disciform stromal keratitis weeks after chickenpox. This corneal inflammation may recur even after initial treatment, indicating a need for ongoing monitoring.

Area of Science:

  • Ophthalmology
  • Virology
  • Infectious Diseases

Background:

  • Disciform stromal keratitis is a form of corneal inflammation.
  • Acute vesicular exanthema, commonly known as chickenpox, is caused by the varicella-zoster virus.

Observation:

  • Five patients developed disciform stromal keratitis weeks after acute vesicular exanthema.
  • Serologic tests confirmed recent varicella infection in some patients.
  • Three patients experienced recurrent corneal inflammation despite initial corticosteroid treatment.

Findings:

  • Varicella-zoster virus is identified as a causative agent of disciform stromal keratitis.
  • The onset of keratitis can be delayed by several weeks post-exanthema.
  • Recurrence of corneal inflammation is a significant clinical feature.

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Implications:

  • This study highlights varicella-zoster virus as an important cause of delayed and recurrent disciform stromal keratitis.
  • Ophthalmologists should consider varicella-zoster virus in the differential diagnosis of stromal keratitis, especially following chickenpox.
  • Awareness of potential recurrence is crucial for patient management and prognosis.