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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Glial Cells01:04

Glial Cells

Overview
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...

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Related Experiment Video

Updated: Jun 15, 2026

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain
08:03

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain

Published on: March 10, 2026

Primary central nervous system lymphoma.

Elizabeth R Gerstner1, Tracy T Batchelor

  • 1Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA. egerstner@partners.org

Archives of Neurology
|March 10, 2010
PubMed
Summary
This summary is machine-generated.

Primary CNS lymphoma (PCNSL) is a rare brain tumor. While challenging to study, this review focuses on PCNSL in immunocompetent individuals, exploring its characteristics and management.

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Related Experiment Videos

Last Updated: Jun 15, 2026

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain
08:03

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain

Published on: March 10, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

  • Neurology
  • Oncology
  • Immunology

Background:

  • Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin lymphoma affecting the brain, eyes, or spinal cord.
  • PCNSL accounts for about 3% of primary CNS tumors in the US.
  • Immunodeficiency, particularly HIV infection, is a known risk factor, though incidence has stabilized.

Purpose of the Study:

  • To review primary CNS lymphoma (PCNSL) specifically in immunocompetent hosts.
  • To discuss the challenges in studying this rare disease and establishing a standard of care.
  • To highlight the current understanding of PCNSL in non-immunocompromised individuals.

Main Methods:

  • Literature review focusing on PCNSL in immunocompetent patients.
  • Analysis of epidemiological data and incidence trends.
  • Synthesis of current knowledge on diagnosis and treatment challenges.

Main Results:

  • PCNSL remains a rare and challenging malignancy to study due to its low incidence.
  • Despite potential for durable remissions, relapse is common in PCNSL.
  • The review specifically addresses PCNSL in the absence of congenital or acquired immunodeficiency.

Conclusions:

  • Effective standard of care for PCNSL is difficult to establish due to its rarity.
  • Further research is needed to improve outcomes for PCNSL patients.
  • This review provides insights into PCNSL within the immunocompetent population.