Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low-density lipoprotein complexes with histones.

Z Skrzydlewski

    Acta Biologica Academiae Scientiarum Hungaricae
    |January 1, 1976
    PubMed
    Summary

    Low-density lipoproteins (LDL) form complexes with histones, primarily the arginine-rich fraction, through ionic interactions. These findings elucidate the molecular basis of LDL-histone binding.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The activity of cancer procoagulant in cases of uterine leiomyomas.

    European journal of gynaecological oncology·2005
    Same author

    Cancer procoagulant as a marker in monitoring the therapy in cases of oesophageal, stomach and colorectal cancer.

    Folia histochemica et cytobiologica·2002
    Same author

    The influence of green tea on the activity of proteases and their inhibitors in plasma of rats after ethanol treatment.

    Roczniki Akademii Medycznej w Bialymstoku (1995)·2002
    Same author

    [Cancer procoagulant activity in cases of esophageal, stomach and colorectal cancer considering progression degree and histological type of cancer].

    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego·2002
    Same author

    [Diagnostic value of testing the procoagulant activity of neoplasms in cases of stomach and esophageal neoplasms].

    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego·2001
    Same author

    [Cancer procoagulant (CP): the new biochemical marker in oncologic diagnosis].

    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego·2000

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Lipid Metabolism

    Background:

    • Low-density lipoproteins (LDL) are key carriers of cholesterol.
    • Histones are proteins that package DNA.
    • Interactions between lipoproteins and nuclear proteins are not fully understood.

    Purpose of the Study:

    • To investigate the formation of complexes between LDL and histones.
    • To identify which histone fractions interact with LDL.
    • To determine the binding mechanism between LDL and histones.

    Main Methods:

    • Isolation and characterization of LDL.
    • Fractionation of total histone.
    • Complex formation assays.
    • Analysis of binding interactions.

    Main Results:

    • LDL form both soluble and insoluble complexes with total histone.
    • The arginine-rich histone fraction predominantly forms complexes with LDL.
    • LDL bind to histones via ionic interactions.

    Conclusions:

    • LDL interact with histones, suggesting a potential role in cellular processes.
    • The arginine-rich histone fraction is the primary binding partner for LDL.
    • Ionic binding is the main mechanism mediating LDL-histone complex formation.

    Related Experiment Videos