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Neoplasms associated with pulmonary eosinophilic granuloma
J F Tomashefski1, A Khiyami, J Kleinerman
1Department of Pathology, Metro-Health Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109.
Archives of Pathology & Laboratory Medicine
|May 1, 1991
Summary
Pulmonary eosinophilic granuloma (PEG) is frequently associated with benign or malignant tumors, especially in older patients. This suggests a potential link between PEG and neoplasms, with smoking as a shared risk factor.
Area of Science:
- Oncology
- Pulmonology
- Pathology
Background:
- Pulmonary eosinophilic granuloma (PEG) is a rare lung disease.
- The association between PEG and other neoplasms requires further investigation.
Observation:
- A study of 21 PEG patients revealed a high prevalence (48%) of associated benign or malignant tumors.
- Tumors included lung carcinomas, lymphomas, and extrapulmonary carcinomas.
- Patients with tumors were significantly older at PEG diagnosis.
Findings:
- Half of PEG-associated tumors showed S100 protein-positive cells, similar to control neoplasms.
- Cigarette smoking is a risk factor for both PEG and lung cancer.
- PEG can mimic pulmonary metastases in patients with underlying malignancies.
Implications:
- The findings suggest a possible non-random association between PEG and neoplasms.
- Further research is needed to confirm the link and elucidate underlying mechanisms.
- Awareness of this association is crucial for accurate diagnosis and patient management.