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Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 15, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Osteosarcoma multidisciplinary approach to the management from the pathologist's perspective.

A Kevin Raymond1, Norman Jaffe

  • 1Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA. kraymond@mdanderson.org

Cancer Treatment and Research
|March 10, 2010
PubMed
Summary

Osteosarcoma, a primary bone cancer, is not a single disease but a family of tumors. Differentiating conventional osteosarcoma from its variants is crucial for targeted therapy and accurate treatment analysis.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Related Experiment Videos

Last Updated: Jun 15, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

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Published on: April 12, 2019

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

  • Oncology
  • Pathology
  • Bone Tumors

Background:

  • Osteosarcoma is a primary malignant bone tumor characterized by neoplastic cells producing osteoid.
  • It predominantly affects young males, commonly involving long bones and exhibiting aggressive local behavior with early metastasis.
  • Osteosarcoma encompasses a spectrum of neoplasms, with 75% classified as 'Conventional Osteosarcoma' and 25% as 'Variants' due to distinct biological characteristics.

Purpose of the Study:

  • To delineate the classification of osteosarcoma based on histological and clinical parameters.
  • To emphasize the importance of distinguishing conventional osteosarcoma from its variants for accurate treatment strategies.
  • To provide a pathologist's perspective on osteosarcoma management and assessment of preoperative chemotherapy response.

Main Methods:

  • Histological analysis to identify osteoid production by neoplastic cells.
  • Classification based on tumor matrix (bone, cartilage, fibrous tissue) for conventional subtypes.
  • Identification of variants based on clinical factors, histological findings, and location of origin.

Main Results:

  • Conventional osteosarcoma subtypes include osteoblastic, chondroblastic, and fibroblastic, based on dominant matrix.
  • Variants possess unique biological behaviors, necessitating exclusion from conventional osteosarcoma treatment data analysis.
  • A disciplined approach to classification supports 'Classification Based Therapy' or 'Therapy Based Osteosarcoma'.

Conclusions:

  • Accurate diagnosis and subclassification of osteosarcoma are essential for effective, individualized treatment strategies.
  • Distinguishing variants from conventional osteosarcoma ensures homogenous patient groups for clinical trials and therapeutic development.
  • Pathological assessment plays a critical role in guiding osteosarcoma management and evaluating treatment efficacy.