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Related Concept Videos

Classification of Bones01:18

Classification of Bones

The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Metastasis02:30

Metastasis

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Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 15, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Molecular classification of osteosarcoma.

Ching C Lau1

  • 1Cancer Genomics Program, Texas Children's Cancer Center, 6621 Fannin Street, MC 3-3320, Houston, TX 77030, USA. cclau@txccc.org

Cancer Treatment and Research
|March 10, 2010
PubMed
Summary
This summary is machine-generated.

A new 45-gene signature accurately predicts chemotherapy response in pediatric osteosarcoma patients before treatment. This genomic approach offers personalized care for improved patient outcomes.

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RNA Fluorescence In Situ Hybridization for Long Non-Coding RNA Localization in Human Osteosarcoma Cells
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RNA Fluorescence In Situ Hybridization for Long Non-Coding RNA Localization in Human Osteosarcoma Cells

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Related Experiment Videos

Last Updated: Jun 15, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

RNA Fluorescence In Situ Hybridization for Long Non-Coding RNA Localization in Human Osteosarcoma Cells
05:27

RNA Fluorescence In Situ Hybridization for Long Non-Coding RNA Localization in Human Osteosarcoma Cells

Published on: June 16, 2023

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

  • Genomics
  • Molecular Biology
  • Oncology

Background:

  • Genomic technologies are advancing cancer diagnosis and prognosis.
  • Molecular markers can identify patient subgroups for targeted therapies.
  • Predicting chemotherapy response is crucial for osteosarcoma treatment.

Purpose of the Study:

  • To identify a gene expression signature for predicting chemotherapy response in pediatric osteosarcoma.
  • To develop a predictive tool for chemoresistance before treatment initiation.

Main Methods:

  • Gene expression profiling was used for molecular classification of osteosarcoma.
  • A 45-gene signature was identified to differentiate between responders and non-responders.

Main Results:

  • A 45-gene signature was identified that accurately discriminates between good and poor responders to chemotherapy.
  • The classifier achieved 100% accuracy in predicting chemoresponse prior to treatment.

Conclusions:

  • Genomic profiling can revolutionize osteosarcoma diagnosis and prognostication.
  • Predictive, personalized care based on genomic signatures can improve patient outcomes.