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Licorice - or more?

H Leitolf1, K C S Dixit, C E Higham

  • 1Medizinische Hochschule Hannover, Department Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|March 10, 2010
PubMed
Summary
This summary is machine-generated.

Excessive licorice consumption caused a patient's hypertension and hypokalemia due to an aldosterone-producing adrenal adenoma. Surgical removal normalized his condition, resolving high blood pressure and low potassium levels.

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Area of Science:

  • Endocrinology
  • Nephrology
  • Oncology

Background:

  • A 57-year-old male presented with a six-year history of poorly controlled hypertension.
  • He was incidentally found to have hypokalemia, with no history of diuretic or laxative use.

Observation:

  • Detailed history revealed daily consumption of 300-500g of licorice.
  • Initial investigations showed normal electrolytes with supplementation, but elevated morning aldosterone and undetectable renin activity.
  • Hormonal profiles revealed elevated 17-hydroxyprogesterone and androstenedione, with low testosterone.

Findings:

  • Stopping licorice intake led to decreased serum potassium and increased urinary aldosterone excretion.
  • Abdominal imaging identified a left adrenal mass, confirmed as an aldosterone-producing adenoma post-surgery.
  • Post-adrenalectomy, aldosterone and potassium levels normalized, and hypertension resolved without medication.

Implications:

  • This case highlights licorice as a potential cause of secondary hypertension and hypokalemia mimicking primary aldosteronism.
  • Early identification and management of licorice ingestion are crucial for diagnosing and treating such endocrine disorders.
  • Surgical intervention for aldosterone-producing adenomas can lead to complete resolution of hypertension and electrolyte imbalances.