Related Experiment Video
Updated: Jun 15, 2026

09:01
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
Published on: July 3, 2025
Temporal proteomic analysis of IGF-1R signalling in MCF-7 breast adenocarcinoma cells
J Patrick Murphy1, Devanand M Pinto
1Department of Biology, Dalhousie University, Halifax, NS, Canada.
Proteomics
|March 10, 2010
Abstract:
Dysregulation of the insulin-like growth factor 1 receptor signalling network is implicated in tumour growth and resistance to chemotherapy. We explored proteomic changes resulting from insulin-like growth factor 1 stimulation of MCF-7 adenocarcinoma cells as a function of time. Quantitative analysis using iTRAQ reagents and 2-D LC-MS/MS analysis of three biological replicates resulted in the identification of 899 proteins (p

