Related Experiment Video

Updated: Jun 15, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

Early vascular phenotypes in the genesis of hypertension

Empar Lurbe1, Maria Isabel Torró

  • 1Department of Pediatrics, Consorcio Hospital General, University of Valencia, Avda Tres Cruces s/n, 46014 Valencia, Spain. empar.lurbe@uv.es

Pediatric Nephrology (Berlin, Germany)
|March 10, 2010
PubMed

Insights

Childhood blood pressure is a key indicator of future cardiovascular risk. Early vascular changes can be detected using non-invasive methods and umbilical cord analysis, aiding in risk prediction.

Area of Science:

  • Cardiovascular health
  • Pediatric cardiology
  • Vascular biology

Background:

  • Cardiovascular complications in adults often originate from early-life risk factors.
  • Childhood blood pressure is a measurable marker for potential future cardiovascular risk.
  • Early vascular alterations can be identified through various assessment techniques.

Purpose of the Study:

  • To review surrogate markers for early vascular alterations.
  • To describe the information obtained from umbilical cord vessels.
  • To highlight the importance of early cardiovascular risk assessment.

Main Methods:

  • Indirect assessment using non-invasive techniques.
  • Estimation of blood pressure components.
  • Measurement of pulse wave velocity and reflecting waves.
  • Direct assessment via umbilical vessel examination.

Main Results:

  • Non-invasive methods provide valuable, repeatable data on vascular health.
  • Umbilical vessel examination offers additional insights into early vascular changes.
  • Childhood blood pressure is both a cause and consequence of early vascular alterations.

Conclusions:

  • Surrogate markers are crucial for identifying early vascular changes.
  • Umbilical cord assessment provides direct information on fetal vascular health.
  • Early detection of vascular alterations in childhood can inform future cardiovascular risk management.

More Related Videos

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography10:48

Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography

Published on: July 6, 2015

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...