Morphological changes induced by Caesalpinia bonducella seed extract on rat sperm: scanning electron microscope study

Area of Science:

• Reproductive biology
• Pharmacology
• Toxicology

Background:

• Caesalpinia bonducella is traditionally used for various medicinal purposes.
• Understanding the effects of plant extracts on male reproductive health is crucial.

Purpose of the Study:

• To investigate the effects of Caesalpinia bonducella seed extract on sperm morphology in albino rats.
• To elucidate the potential mechanisms behind observed morphological changes.

Main Methods:

• Albino rats were treated with graded doses of an alcoholic seed extract of Caesalpinia bonducella.
• Sperm morphology was analyzed using scanning electron microscopy (SEM).
• Comparison was made between treated groups and a control group.

Main Results:

• Significant morphological abnormalities were observed in sperm from treated rats.
• Disturbances in the plasma and acrosomal membranes were evident.
• Changes included altered sperm head shape, size, and bulging of the acrosomal membrane.

Conclusions:

• Caesalpinia bonducella seed extract induces sperm morphological changes in rats.
• These changes may result from protein disturbance and altered cauda epididymal milieu.
• Potential androgen deficiency could be a contributing factor to the observed effects.