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Pattern of retinopathy of prematurity and its correlation with insulin-like growth factor-1 (IGF-1)

Shri Kant1, Usha, Bhatia

  • 1Department of Ophthalmology, Institute of Medical Sciences Banaras Hindu University, Varanasi-221005, India. Kantshri@sify.com

Annals of Ophthalmology (Skokie, Ill.)
|March 11, 2010
PubMed

Insights

Serum insulin-like growth factor-1 (IGF-1) levels did not correlate with retinopathy of prematurity (ROP) severity in premature infants. All infants developed mild ROP, regardless of IGF-1 levels.

Area of Science:

  • Neonatology
  • Ophthalmology
  • Endocrinology

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Insulin-like growth factor-1 (IGF-1) plays a role in vascular development and has been investigated as a potential biomarker for ROP.

Purpose of the Study:

  • To investigate the correlation between serum insulin-like growth factor-1 (IGF-1) levels and the development and severity of retinopathy of prematurity (ROP) in premature infants.

Main Methods:

  • Serum samples were collected from 15 premature infants.
  • IGF-1 levels were measured.
  • ROP staging and zone involvement were assessed and correlated with IGF-1 levels.

Main Results:

  • 73% of infants developed Stage 1 ROP, and 27% developed Stage 2 ROP.
  • Zone III ROP did not progress beyond Stage 1, and Zone II ROP did not progress beyond Stage 2.
  • No significant correlation was found between serum IGF-1 levels and the severity or stage of ROP.

Conclusions:

  • Serum IGF-1 levels do not appear to be a reliable predictor of ROP severity in this cohort of premature infants.
  • Further research is needed to fully elucidate the role of growth factors in ROP pathogenesis.

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