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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...

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Related Experiment Video

Updated: Jun 15, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Pain management in multiple myeloma.

Pasquale Niscola1, Laura Scaramucci, Claudio Romani

  • 1Division of Haematology, S. Eugenio Hospital, Rome, Italy. pniscola@gmail.com

Expert Review of Anticancer Therapy
|March 11, 2010
PubMed
Summary

Multiple myeloma (MM) pain significantly impacts quality of life. Effective pain management requires understanding diverse pain mechanisms and a multidisciplinary approach integrating analgesics and interventions.

Related Experiment Videos

Last Updated: Jun 15, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Area of Science:

  • Oncology
  • Pain Medicine
  • Hematology

Background:

  • Pain is a significant and debilitating symptom in multiple myeloma (MM).
  • Pain in MM arises from various causes, including disease complications, iatrogenic factors, and unrelated conditions.
  • Severe pain negatively affects patients' quality of life and functional status.

Purpose of the Study:

  • To review common pain syndromes in multiple myeloma patients.
  • To elucidate the underlying pain mechanisms in MM.
  • To discuss current treatment strategies for pain management in MM.

Main Methods:

  • Literature review of common pain syndromes in multiple myeloma.
  • Analysis of pain mechanisms, including nociceptive and neuropathic pain.
  • Discussion of treatment strategies, including WHO analgesic ladder and multimodal approaches.

Main Results:

  • Most MM patients experience pain, often requiring more than standard analgesics.
  • Skeletal instability and neuropathic mechanisms present challenging pain types.
  • A multidisciplinary approach combining analgesics and causal interventions is crucial.

Conclusions:

  • Understanding MM pain mechanisms is key to effective management.
  • The WHO analgesic ladder is a foundation, but often insufficient for complex MM pain.
  • Multidisciplinary care integrating pharmacological and non-pharmacological strategies is essential for improving MM patient outcomes.