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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

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Related Experiment Video

Updated: Jun 15, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

[Aphasia in elderly patients].

Olivier Moreaud1, Danielle David, Marie-Pierre Brutti-Mairesse

  • 1CMRR et neuropsychologie, Pôle de psychiatrie et neurologie, CHU de Grenoble. OMoreaud@chu-grenoble.fr

Psychologie & Neuropsychiatrie Du Vieillissement
|March 11, 2010
PubMed
Summary
This summary is machine-generated.

Aphasia, common in elderly individuals with neurological conditions, requires comprehensive evaluation. While diagnosis and treatment are similar to younger patients, associated symptoms can complicate therapy.

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Last Updated: Jun 15, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
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Published on: February 2, 2020

Area of Science:

  • Neurology
  • Geriatrics
  • Speech-Language Pathology

Context:

  • Aphasia frequently affects elderly patients due to vascular or neurodegenerative disorders.
  • It can manifest as an isolated symptom post-stroke or progressively as primary progressive aphasia.

Purpose:

  • To outline the diagnostic and therapeutic considerations for aphasia in older adults.
  • To highlight challenges in managing aphasia in the elderly population.

Summary:

  • Diagnosis and treatment of aphasia in the elderly are generally similar to younger individuals.
  • Therapy can be complicated by associated non-linguistic symptoms, fatigability, and comprehension deficits.
  • Comprehensive evaluation including language, cognition, psychopathology, behavior, and neuroimaging (MRI) is crucial.

Impact:

  • Emphasizes the importance of recognizing aphasia amidst other disorders in older patients.
  • Recommends rehabilitation for elderly patients with aphasia to improve communication.
  • Acknowledges that associated symptoms can significantly limit therapeutic outcomes.