Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Conclusion and future prospects].

R Monier1

  • 1Laboratoire d'oncologie moléculaire, institut Gustave Roussy, Villejuif, France.

Bulletin Du Cancer
|January 1, 1991
PubMed
Summary

Genetic events in tumorigenesis involve proto-oncogenes and anti-oncogenes, regulating cell growth. Understanding these genes aids cancer prediction, prognosis, and future therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The causes of cancer in France.

Annals of oncology : official journal of the European Society for Medical Oncology·2008
Same author

Origin and make up of the human sural nerve.

Surgical and radiologic anatomy : SRA·2002
Same author

[Fundamental aspects: mechanisms of carcinogenesis and dose-effect relationship].

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·2000
Same author

The various models of carcinogenesis. Susceptibility genes, mutations, epigenetic processes.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie·1999
Same author

Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.

Oncogene·1998
Same author

Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation.

Proceedings of the National Academy of Sciences of the United States of America·1997

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Tumorigenesis involves genetic alterations affecting cell growth regulation.
  • Two key gene classes, proto-oncogenes and anti-oncogenes, control cellular proliferation and growth.
  • Dysregulation of these genes is fundamental to cancer development.

Purpose:

  • To elucidate the roles of proto-oncogenes and anti-oncogenes in tumorigenesis.
  • To highlight the significance of genetic events in cancer predisposition.
  • To explore the clinical applications of genetic insights in oncology.

Summary:

  • Proto-oncogenes promote cell proliferation, while anti-oncogenes inhibit it.
  • Genetic predisposition to cancer is linked to specific gene mutations.
  • Observations on proto-oncogenes currently offer prognostic value in certain cancers.

Impact:

  • Identification of cancer-predisposing genes enhances predictive medicine.
  • Understanding gene functions in tumorigenesis informs prognostic assessments.
  • Future therapeutic strategies will likely target these genetic pathways for cancer treatment.

Related Experiment Videos