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Updated: Jun 15, 2026
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Wnt and Notch signaling pathways selectively regulating hematopoiesis
Kun Zhou1, Lifang Huang, Zhigang Zhou
1Department of Hematology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Annals of Hematology
|March 11, 2010
Summary
Wnt and Notch signaling pathways are key regulators of hematopoietic stem and progenitor cell (HSPC) development. Their precise balance orchestrates blood cell formation during embryogenesis, offering insights for ex vivo cell expansion.
Area of Science:
- Developmental Biology
- Hematopoiesis
- Stem Cell Biology
Background:
- Hematopoietic stem and progenitor cells (HSPCs) generate all adult blood cells.
- HSPC development occurs sequentially in specific embryonic regions and organs.
- Understanding HSPC expansion mechanisms is crucial for ex vivo cell generation.
Purpose of the Study:
- To investigate the role of Wnt and Notch signaling in definitive HSPC expansion during embryogenesis.
- To analyze spatial and temporal gene expression patterns of Wnt and Notch signaling members.
Main Methods:
- Analysis of spatial and temporal gene expression patterns.
- Focus on Wnt and Notch signaling pathway members during hematopoietic development.
Main Results:
- Wnt signaling genes were upregulated in the aorta-gonad-mesonephros (AGM) at E10.5 and fetal liver at E14.5, correlating with progenitor proliferation.
- Notch signaling genes were upregulated in the AGM at E10.5 and bone marrow, correlating with progenitor undifferentiation.
- Wnt and Notch signaling are integrated and selectively regulate hematopoiesis.
Conclusions:
- A spatial and temporal balance between Wnt and Notch signaling orchestrates hematopoietic progenitor progression.
- These findings provide insights into the mechanisms controlling HSPC development and potential for ex vivo expansion.
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03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
02:54Canonical Wnt Signaling Pathway
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
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