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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Mechanical Dissociation of Tissues for Single Cell Analysis Using a Motorized Device
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Published on: November 10, 2023

Nanoparticle technologies for cancer therapy.

Frank Alexis1, Eric M Pridgen, Robert Langer

  • 1Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Handbook of Experimental Pharmacology
|March 11, 2010
PubMed
Summary
This summary is machine-generated.

Nanoparticle drug delivery systems offer innovative cancer treatment strategies. Advanced nanoparticles with multifunctional capabilities show promise in overcoming challenges like drug resistance and metastasis.

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Materials Science

Background:

  • Nanoparticles have emerged as crucial tools in cancer therapy over the past 20 years.
  • Existing clinical nanoparticle formulations include liposomes, polymer-drug conjugates, and micelles.
  • Numerous nanoparticle platforms are progressing through preclinical development.

Purpose of the Study:

  • To review preclinical and clinical nanoparticle technology platforms for cancer therapy.
  • To highlight the impact of these advanced delivery systems on cancer treatment.
  • To discuss the potential of multifunctional nanoparticles in addressing complex cancer challenges.

Main Methods:

  • Review of existing literature on nanoparticle drug delivery systems.
  • Analysis of preclinical and clinical data for various nanoparticle platforms.
  • Examination of emerging nanoparticle technologies incorporating targeting and multifunctionality.

Main Results:

  • A wide array of nanoparticle systems, both organic and inorganic, have been developed.
  • Several nanoparticle formulations are currently in clinical use, with more in preclinical stages.
  • Newer nanoparticles exhibit enhanced sophistication with multifunctional capabilities and targeting strategies.

Conclusions:

  • Nanoparticle drug delivery systems represent a significant advancement in cancer treatment.
  • Multifunctional nanoparticles offer potential solutions for drug resistance and metastatic disease.
  • Continued development of nanoparticle platforms is crucial for improving cancer therapy efficacy.