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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Prevalence of factor V leiden mutation in patients with thrombosis in Tunisia

A Ajem1, A Slama, F B H Slama

  • 1Immunogenetic Unit, Faculty of Medicine of Sousse, Sousse, Tunisia.

Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = Al-Majallah Al-Sihhiyah Li-Sharq Al-Mutawassit
|March 12, 2010
PubMed

This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients (102 with venous thrombosis and 26 with arterial thrombosis) attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients (20.3%) than controls (6.0%). The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified.

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