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Updated: Jun 15, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
Published on: September 27, 2024
[Prevention of cortisone-induced osteoporosis: who, when and what?]
Bérengère Aubry-Rozier1, Olivier Lamy, Jean Dudler
1Centre des maladies osseuses, Hôpital orthopédique, Avenue Pierre-Decker 4, CHUV, 1011 Lausanne. berengere.aubry@chuv.ch
Abstract:
Glucocorticoid-induced osteoporosis is a known phenomenon with already an increased fracture risk at 2.5 mg of prednisone daily over 3 months. This risk appears to be independent of bone densitometry results, in contradiction with published guidelines. With the creation of our Department of Musculoskeletal Medicine, we wanted to edict clear recommendations for the prevention of steroid-induced osteoporosis. In addition to the standard general measures to prevent osteoporosis and calcium and vitamin D supplementation, we advocate the use of a specific treatment for osteoporosis in all cases when the duration of corticosteroid therapy is not strictly limited and shorter than 3 months. Bisphosphonates are the treatment of choice, while the analogue of parathyroid hormone remains an alternative in cases with a very high fracture risk.
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