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[Effects of radix morindae from different processed products on anti-hypoxia and reproductive system of mice]
Shuo Liu1, Hai-yan Ou, Yi-ting Yang
1Infinitus (China) Company Ltd, Guangzhou 510665, China.
Objective:
To investigate the effects of Radix Morindae from different processed products on anti-hypoxia and reproductive system of mice.
Methods:
The experimental study on anti-hypoxia was through the anti-anoxia action under normal-pressure, sodium nitrite poisoning and acute cerebral ischemia anoxia test; the experimental study on reproductive system was through observing the testis weight of immature male mice and the development of accessory sex organs in castrated mice.
Results:
Both Radix Morindae of drying product and salt product could markedly increase the mice breathing time under acute cerebral ischemia anoxia, the salt product also could markedly increase the breathing frequency, prolong the mice survival time under atmospheric hypoxia and increase the testis weight of immature male mice.
Conclusion:
Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.
Insights
Both dried and salt-processed Radix Morindae enhance anti-hypoxia and reproductive health in mice. The salt-processed form demonstrated superior efficacy in these effects.
Area of Science:
- Pharmacology
- Traditional Chinese Medicine
- Physiology
Background:
- Radix Morindae is a component of traditional Chinese medicine.
- Understanding the impact of different processing methods on its efficacy is crucial.
Purpose of the Study:
- To evaluate the effects of dried and salt-processed Radix Morindae on anti-hypoxia and the reproductive system in mice.
- To compare the efficacy of different Radix Morindae preparations.
Main Methods:
- Anti-hypoxia was assessed using normal-pressure anoxia, sodium nitrite poisoning, and acute cerebral ischemia models.
- Reproductive system effects were evaluated by observing testis weight in immature male mice and accessory sex organ development in castrated mice.
Main Results:
- Both dried and salt-processed Radix Morindae significantly increased survival time under acute cerebral ischemia anoxia.
- Salt-processed Radix Morindae notably improved breathing frequency, prolonged survival under atmospheric hypoxia, and increased testis weight.
Conclusions:
- Both processed forms of Radix Morindae exhibit beneficial effects on anti-hypoxia and the reproductive system in mice.
- Salt-processed Radix Morindae showed enhanced efficacy compared to the dried product.
