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Updated: Jun 15, 2026
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
[Studies on flavonoids and their antioxidant activities of Artemisia annua]
Guo-en Yang1, Li Bao, Xiao-qi Zhang
1Department of Phytochemistry, China Pharmaceutical University, Nanjing 210038, China. 200203684@sina.com.cn
Objective:
To study the flavonoids and their antioxidant activities of Artemisia annua.
Methods:
Isolation and purification were carried out by silica gel and Sephadex LH-20 column chromatographies. Compounds were identified by physicochemical properties and spectral analysis, then their antioxidant activities were evaluated by ORAC assay.
Results:
Five flavonoids were isolated from the plant. Their structures were identified as 5-hydroxy-3,7,4'-trimethoxyflavone(1), 5-hydroxy-6,7,3',4'-tetramethoxyflavonol(2), blumeatin(3), 5, 4'-dihydroxy-3,7,3'-trimethoxyflavone(4) and quercetin(5), respectively. Compounds 1-5 could slow up the attenuation rate of the fluorescence induced by AAPH.
Conclusion:
Compounds 1-3 are isolated from the plant for the first time. Compounds 1-5 all possess the potential antioxidant activities.
