Oseltamivir-resistant 2009-2010 pandemic influenza A (H1N1) in an immunocompromised patient
P A Chan1, N T Connell, A M Gabonay
1Division of Infection Disease, Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA. pchan@lifespan.org
Abstract:
Although neuraminidase inhibitors are active against most 2009-2010 pandemic influenza A (H1N1) swine-origin strains, sporadic cases of oseltamivir resistance have been described. Since April 2009, 54 cases of oseltamivir-resistant H1N1 swine-origin have been reported in the USA (http://www.cdc.gov/flu/weekly/; accessed 1 February 2010). Approximately 1.4% of tested isolates are oseltamivir resistant. We report a patient with an underlying hematological malignancy who was hospitalized with influenza A (H1N1) swine-origin and whose strain developed oseltamivir resistance during therapy.
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