Association of higher adiposity and wheezing in infants with lower respiratory illnesses

Hye Mi Jee1, Hyun Kyong Seo, Se Eun Hyun

  • 1Department of Pediatrics, CHA Bundang Medical Center, CHA University, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea.

Insights

Higher weight for height (WFH) Z-scores are linked to increased wheezing in infants with lower respiratory tract infections (LRTI). Maintaining appropriate weight may reduce wheezing risk in infants with respiratory conditions.

Area of Science:

  • Pediatrics
  • Respiratory Medicine
  • Public Health

Background:

  • Asthma and obesity rates are rising globally.
  • Existing research suggests a link between obesity and asthma.
  • Infant wheezing is a common symptom of lower respiratory tract infections (LRTI).

Purpose of the Study:

  • To investigate the association between weight for height (WFH) Z-score and wheezing in infants diagnosed with their first episode of LRTI.
  • To determine if higher WFH Z-scores independently predict wheezing in infants.

Main Methods:

  • Retrospective review of medical charts for infants under 1 year old admitted with their first LRTI episode between 2000 and 2008.
  • Infants were categorized into six groups based on their WFH Z-score.
  • Multivariate logistic regression analysis was used to identify independent predictors of wheezing.

Main Results:

  • Wheezing occurred more frequently in infants with higher WFH Z-scores.
  • Infants aged 3-6 months and 6-9 months with wheezing had significantly higher WFH Z-scores.
  • Higher WFH Z-score, younger age, and male gender were independently associated with wheezing.

Conclusions:

  • A higher WFH Z-score is an independent risk factor for wheezing in infants with LRTI.
  • Promoting appropriate weight for age in infants may help mitigate the risk of wheezing.
  • This finding highlights the importance of weight management in infant respiratory health.
Abstract

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