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Published on: May 10, 2024
Association of higher adiposity and wheezing in infants with lower respiratory illnesses
Hye Mi Jee1, Hyun Kyong Seo, Se Eun Hyun
1Department of Pediatrics, CHA Bundang Medical Center, CHA University, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea.
Insights
Higher weight for height (WFH) Z-scores are linked to increased wheezing in infants with lower respiratory tract infections (LRTI). Maintaining appropriate weight may reduce wheezing risk in infants with respiratory conditions.
Area of Science:
- Pediatrics
- Respiratory Medicine
- Public Health
Background:
- Asthma and obesity rates are rising globally.
- Existing research suggests a link between obesity and asthma.
- Infant wheezing is a common symptom of lower respiratory tract infections (LRTI).
Purpose of the Study:
- To investigate the association between weight for height (WFH) Z-score and wheezing in infants diagnosed with their first episode of LRTI.
- To determine if higher WFH Z-scores independently predict wheezing in infants.
Main Methods:
- Retrospective review of medical charts for infants under 1 year old admitted with their first LRTI episode between 2000 and 2008.
- Infants were categorized into six groups based on their WFH Z-score.
- Multivariate logistic regression analysis was used to identify independent predictors of wheezing.
Main Results:
- Wheezing occurred more frequently in infants with higher WFH Z-scores.
- Infants aged 3-6 months and 6-9 months with wheezing had significantly higher WFH Z-scores.
- Higher WFH Z-score, younger age, and male gender were independently associated with wheezing.
Conclusions:
- A higher WFH Z-score is an independent risk factor for wheezing in infants with LRTI.
- Promoting appropriate weight for age in infants may help mitigate the risk of wheezing.
- This finding highlights the importance of weight management in infant respiratory health.
Aim:
The incidences of asthma and obesity have been steadily increasing over the past two decades, with several studies showing a relationship between these conditions. We investigated the influence of higher weight for height (WFH) Z-score on wheezing in infants with lower respiratory tract infections (LRTI).
Methods:
We reviewed the medical charts of all infants younger than l year of age who were admitted with the first episode of LRTI between 2000 and 2008. Subjects were classified into six groups according to WFH Z-score.
Results:
Wheezing was more frequent in infants with higher WFH Z-scores. Especially, wheezing infants aged 3-6 months and 6-9 months had significantly higher WFH Z-scores than had their non-wheezing counterparts (p = 0.05 and p < 0.01 respectively). Multivariate logistic regression showed that age (OR = 0.76, p < 0.001), male gender (OR = 1.61, p = 0.005) and WFH Z-score (OR = 1.12, p = 0.007) were independently associated with wheezing.
Conclusion:
In this study we could show that a higher WFH Z-score was independently associated with wheezing in infancy. Attainment of appropriate weight for age may reduce the risk of wheezing in infants with respiratory diseases.
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