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Surveillance of human astrovirus circulation in Italy 2002-2005: emergence of lineage 2c strains
S De Grazia1, M A Platia, V Rotolo
1Dipartimento di Scienze per la Promozione della Salute G. D'Alessandro, Sezione di Microbiologia, Università di Palermo, Italy.
Abstract:
By screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95% of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5′ end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.
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