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Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

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Related Experiment Video

Updated: Jun 15, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Feline primary hyperaldosteronism.

Rhonda L Schulman1

  • 1Animal Specialty Group, 4641 Colorado Boulevard, Los Angeles, CA 90039, USA. rhondaschulman@gmail.com

The Veterinary Clinics of North America. Small Animal Practice
|March 12, 2010
PubMed
Summary

Primary hyperaldosteronism (PHA) in cats is increasingly diagnosed, often presenting with high blood pressure and low potassium. Early detection and treatment, including surgery or medication, lead to good outcomes for feline hypertension.

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Last Updated: Jun 15, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
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Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

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Published on: September 1, 2015

Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Internal Medicine

Background:

  • Primary hyperaldosteronism (PHA) is an increasingly recognized endocrine disorder in cats.
  • Key clinical signs include systemic hypertension and hypokalemia.
  • Adrenal gland abnormalities are often detected via ultrasound.

Purpose of the Study:

  • To review the diagnosis and management of primary hyperaldosteronism in cats.
  • To highlight the importance of considering PHA in hypertensive cats.
  • To discuss the implications of diagnostic criteria on disease recognition.

Main Methods:

  • Review of clinical findings, diagnostic methods, and treatment outcomes for feline PHA.
  • Analysis of diagnostic criteria, including aldosterone and renin levels.
  • Discussion of imaging findings, particularly adrenal ultrasound.

Main Results:

  • Diagnosis relies on elevated aldosterone levels, often with hypokalemia and low renin activity.
  • Surgical excision of affected adrenal glands offers a good prognosis.
  • Medical management can stabilize patients, but early detection is crucial.

Conclusions:

  • Increased awareness and earlier diagnosis are expected to raise the reported incidence of PHA in cats.
  • Hypokalemia alone may not be a sufficient screening criterion, potentially leading to underdiagnosis.
  • PHA should be a key differential diagnosis for refractory or idiopathic hypertension in feline patients.