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Updated: Jun 15, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
Selenoproteins and the aging brain
Shu Zhang1, Caroline Rocourt, Wen-Hsing Cheng
1Department of Nutrition and Food Science, University of Maryland, 0112 Skinner Building, College Park, MD 20742, USA.
Abstract:
Selenium (Se) is an essential trace mineral mediating its biological function primarily through selenoproteins. Accumulated lines of evidence indicate important roles of selenoproteins in the maintenance of optimal brain functions via redox regulation. Decreased expression of several selenoproteins is associated with the pathologies of a few age-associated neurodisorders, including Parkinson's disease, Alzheimer's disease and epilepsy. Recent advances using genetically manipulated mouse models demonstrate that selenoproteins offer protection against neurodegeneration primarily through redox regulation. Therapies targeting specific selenoproteins influencing redox regulation could delay the onset of neurodisorders, improve quality of life of patients already affected, and perhaps rescue patients with certain diseases by using novel gene therapies.
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