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Endothelin has biological actions at pathophysiological concentrations.

A Lerman1, F L Hildebrand, L L Aarhus

  • 1Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905.

Circulation
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

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Elevated plasma endothelin concentrations, seen in disease states, biologically impact cardiorenal and endocrine function. This study confirms endothelin

Area of Science:

  • Cardiovascular Physiology
  • Renal Physiology
  • Endocrinology

Background:

  • Endothelin is an endothelium-derived peptide causing smooth muscle contraction.
  • Pharmacological endothelin concentrations induce vasoconstriction and activate the renin-angiotensin-aldosterone system.
  • Increased plasma endothelin is observed in conditions with vasoconstriction, but its biological activity is unclear.

Purpose of the Study:

  • To determine the biological actions of endothelin on cardiorenal and endocrine function.
  • To investigate endothelin's effects at pathophysiological plasma concentrations.

Main Methods:

  • Experiments were conducted in anesthetized dogs.
  • Endothelin-1 was infused intravenously to double circulating concentrations in one group.

Related Experiment Videos

  • A control group received saline vehicle.

    • Main Results:

    • A twofold increase in plasma endothelin did not alter mean blood pressure or coronary blood flow.
    • Heart rate and cardiac output decreased.
    • Increased renal and systemic vascular resistances and antinatriuresis were observed.

    Conclusions:

    • Endothelin exerts biological effects at pathophysiological plasma concentrations.
    • Endogenous endothelin may play a functional role in regulating cardiovascular, renal, and endocrine function.
    • Endothelin acts as a vasoconstrictor peptide hormone in disease states.