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Comparison of exercise testing with studies of coronary flow reserve in patients with microvascular angina
R O Cannon1, W H Schenke, A Quyyumi
1Cardiovascular Diagnosis Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. 20892.
Insights
Abnormal small coronary artery function, or microvascular angina, can cause chest pain and ischemia. Exercise testing reveals abnormal left ventricular ejection fraction responses in patients with ischemic or bundle branch block patterns, indicating impaired coronary flow.
Area of Science:
- Cardiology
- Physiology
Background:
- Abnormal small coronary artery function can lead to anginal symptoms and ischemia in patients with normal epicardial coronary arteries.
- Microvascular angina is characterized by limited coronary flow responses to stress.
Purpose of the Study:
- To evaluate the exercise hemodynamic correlates of coronary flow abnormalities in patients with microvascular angina.
- To compare exercise responses between patients with microvascular angina and those with normal coronary flow.
Main Methods:
- Analysis of 105 patients with microvascular angina and 27 normal controls.
- Assessment of exercise hemodynamic responses using radionuclide angiography and electrocardiography during treadmill testing.
- Pharmacological stress testing with ergonovine and dipyridamole to evaluate coronary vasodilation.
Main Results:
- Patients with microvascular angina exhibiting ischemic or bundle branch block responses on exercise ECG showed abnormal left ventricular ejection fraction responses.
- The normal group and microvascular angina patients with normal exercise ECGs demonstrated an increase in ejection fraction during exercise.
- Dipyridamole induced less coronary vasodilation in microvascular angina patients with abnormal exercise ECG responses compared to those with normal exercise ECGs.
Conclusions:
- Exercise testing can identify abnormal left ventricular ejection fraction responses associated with microvascular angina.
- Impaired coronary vasodilation during pharmacological stress is linked to exercise-induced ischemic or bundle branch block patterns in microvascular angina.
Abstract:
Abnormal small coronary artery function may cause limited coronary flow responses to stress, resulting in anginal symptoms and ischemia in some patients with chest pain despite angiographically normal coronary arteries. To assess the exercise hemodynamic correlates of coronary flow abnormalities measured in the cardiac catheterization laboratory, 105 patients with microvascular angina (defined as an increase in coronary vascular resistance during pacing stress after ergonovine administration in the absence of significant epicardial constriction and associated with provocation of the patient's typical chest pain) and 27 patients without any coronary flow abnormality (normal) were analyzed. Of the 105 patients with microvascular angina, 75 had normal electrocardiographic responses to treadmill exercise testing, 22 had ischemic responses, and eight had bundle branch block during exercise. All 27 normal patients had normal electrocardiographic responses to exercise. Patients with ischemic electrocardiographic responses (0 +/- 7%, p less than 0.01), and those with bundle branch block (-2 +/- 6%, p less than 0.01) had abnormal left ventricular ejection fraction responses to exercise compared with the normal group, who demonstrated an 8 +/- 6% increase in left ventricular ejection fraction by radionuclide angiography during exercise, and microvascular angina patients with a normal electrocardiographic response to exercise, who demonstrated a 5 +/- 7% increase in ejection fraction. Although the microvascular response to ergonovine was no different among the three microvascular angina exercise groups, the administration of dipyridamole caused less coronary vasodilation in those patients with apparently ischemic or bundle branch block responses to exercise compared with those with normal electrocardiograms during exercise.(ABSTRACT TRUNCATED AT 250 WORDS)